If they are not, a disconnected network will result and the network weighting will not be optimal. It does not matter which function they are related by, as long as that function is captured somehow by some functional association networks in the GeneMANIA system. If your query binary option mania consists of 6 or more genes, GeneMANIA will calculate gene list-specific weights.
If your query list has less than 6 genes, GeneMANIA will make gene function predictions based on GO annotations patterns. The GeneMANIA Cytoscape app is capable of handling larger gene lists. The number of resultant genes, the number of resultant attributes, and the weighting method can be configured in the advanced options. GeneMANIA network categories GeneMANIA searches many large, publicly available biological datasets to find related genes. These include protein-protein, protein-DNA and genetic interactions, pathways, reactions, gene and protein expression data, protein domains and phenotypic screening profiles.
Two genes are linked if their expression levels are similar across conditions in a gene expression study. Two gene products are linked if they were found to interact in a protein-protein interaction study. Two genes are functionally associated if the effects of perturbing one gene were found to be modified by perturbations to a second gene. These data are collected from primary studies and BioGRID. Shared protein domains: Protein domain data. Two gene products are linked if they have the same protein domain. Co-localization: Genes expressed in the same tissue, or proteins found in the same location.